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Furthermore, dysfunctional cholesterol metabolism, mediated by ApoE, particularly the ApoE4 variant, disrupts lipid homeostasis, leading to excessive LDs accumulation in microglia and astrocytes (Qi et al., 2021)

"A comprehensive review of lipidomics and its application to assess food obtained from farm animals." Food Science of Animal Resources 42.1 (2022): 1.

PLoS Med 6(2): e1000031

Unbroken cells and large debris were removed by centrifugation at 10,000 g for 30 min at 4 C

Thirdly, the mechanism of action of MOTS-c on bone metabolism has been under-investigated, and most studies focus on the ex vivo mechanism, and fewer on the in vivo mechanism

So far, studies have separately explored the roles of ECM type and substrate stiffness for MC biology