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Often AMPA and NMDA receptors are located on the same dendritic spine , and synaptic strengthening through long-term potentiation can be localized to a particular spine or a collection of adjacently-positioned spines

[DOI] [PubMed] [Google Scholar] 53.Ueland P.M., Schneede J

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[DOI] [PubMed] [Google Scholar] 426.Hofmann M.A., Schiekofer S., Isermann B., Kanitz M., Henkels M., Joswig M., Treusch A., Morcos M., Weiss T., Borcea V., et al

Also, extracellular ATPs can induce drug resistance

B12 Injections: For those with pernicious anaemia or severe malabsorption, the NHS often provides B12 injections (hydroxocobalamin) to bypass the digestive tract entirely