foxo4-dri senolytic peptide human trial 2024 2025 inhibitors targeting FOXO4-p53 interactions and inducing senescent cancer cell-specific apoptosis Senolytics: from pharmacological inhibitors to
Description
Nanotechnology-based carriers, receptor-targeted delivery platforms, intranasal nanoparticle systems, and extracellular vesicle-based formulations have demonstrated improved pharmacokinetics, controlled release, and enhanced CNS accumulation in preclinical studies, with several advanced platforms now progressing into early-phase clinical evaluation for AD and related neurodegenerative disorders
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Sagare, Abhay P
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