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Ketones reduce appetite by either acting directly on the brains chemical messengers or You may be familiar with ketones in the context of ketogenic diets, which are quite popular these days

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This may lead to deficits in long-term potentiation at central excitatory synapses and contribute to cognitive impairments and epilepsy in Rett syndrome (160)

This, in turn, depends on the size of the target tissue which dictates TRT

Too much protein has anti-ketogenic effects because too much protein turns into sugar in the blood (this has been demonstrated to me with my extremely diabetic clients who eat too much protein even though they are staying under 10g carbs a day and it causes blood sugar issues)