hemopyrrollactamuria and glutathione depletion Application of in cancer therapy: Enhanced ROS-based therapy, ferroptosis, chemotherapy Frontiers | Role of Glutathione

As the prevalence of diabetes increases, so does the prevalence of DKD

Torres et al., 2023)

[DOI] [PubMed] [Google Scholar] Tiranti V, Viscomi C, Hildebrandt T, Di Meo I, Mineri R, Tiveron C, Levitt MD, Prelle A, Fagiolari G, Rimoldi M, Zeviani M

Moreover, hepatic ischemic episodes have been shown to alter glucose metabolism in the liver by switching from oxidative phosphorylation to a more proliferativecompatible metabolism, characterized by activation of glycolysis (the Warburg effect)

This dysregulation increases iron storage, promoting M1 polarization (89)

The authors ackowledge support by the bwHPC initiative (high-performance computing in Baden-Wuerttemberg, Germany)