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Increased proteolysis of insulin-like growth factor-binding protein-3 (IGFBP-3) in noninsulin-dependent diabetes mellitus serum, with elevation of a 29-kilodalton (kDa) glycosylated IGFBP-3 fragment contained in the approximately 130- to 150-kDa ternary complex

4.4 Practical considerations in pharmacokinetics and administration routes The synovial cavity, as a natural enclosed space, provides an ideal window for local drug delivery, allowing drugs to act on the lesion site at high concentrations while minimizing systemic exposure and associated potential risks (Yu et al., 2024

J Clin Endocrinol Metab 76:309317 Beshyah SA, Kyd P, Thomas E, Fairney A, Johnston DG (1995) The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults