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Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson's disease

The non-coenzyme action involves participation of thiamine and/or derivatives, including thiamine triphosphate, in the regulation of ACh synaptic function, consistent with the early data on thiamine as a co-mediator of ACh in neuromuscular synapses, and in allosteric action on metabolic enzymes

30, 39 Exposure of primary human airway epithelial cells directly to uric acid failed to induce production of any of these mediators in our model system

Kulawik, CieleckaPiontek, and Zalewski's (2023) investigation found that lycopene and betacarotene, among other phenolic compounds, lower hepatic aminotransferase, a biomarker for inflammation, when present in high serum levels

Therefore, ferroptosis may be the primary pathway through which ischemia-reperfusion injury triggers AKI

PMID: 40983152 Cell Prolif2024 Dec 22:e13794