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doi: 10.1105/tpc.106.043125

in vitro with chemically reactive metabolites derived from several drugs displaying idiosyncratic toxicity, including troglitazone, acetaminophen, clozapine, and diclofenac (Okada et al., 2011

Notably, these specific genes epigenetically modified by DNA hypermethylation regulate cancer response to systemic chemotherapy, making them potential predictive markers for therapy response, as shown in Figure 2

I.et al

In liver cancer, NAPRT expression reflects the ability of the organ to synthesize NAD + 334 , thus highlighting the importance of tissue gene expression to be considered when targeting a particular organ