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The receptor activity-modifying protein transmembrane domain sits at the interface between transmembrane domains 3, 4, and 5 of CLR, and stabilizes CLR extracellular loop 2

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Investigators value it for probing satiety signaling outside the GLP-1 system

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164 In a randomized crossover trial in 50 subjects with male infertility, one month of treatment with a supplement containing pine bark extract plus L-arginine (an amino acid precursor to nitric oxide which regulates blood vessel function) increased semen volume, sperm number and concentration, motility, and vitality, and improved sperm morphology compared with placebo

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