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Description
97A , 484493 (2015)

The lethal dose threshold (LD1) was never achieved in animal safety studies meaning researchers could not identify a dose lethal to 1% of test subjects
The abdomen is the central field, the flanks are the two side panels, the outer thighs are the lower-left and lower-right anchors, and the tricep pads are the upper corners

Such an outcome occurs in situations in which the rat with the operated leg resists minimally or does not rest on the surface at all

doi: 10.1038/nrrheum.2014.53

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