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Enzymes, for example, usually have significantly reduced enzymatic activity, if any activity at all, when they are refolded from the insoluble fraction
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Yucel et al
Mutations in SCO2 are associated with a distinct form of hypertrophic cardiomyopathy and cytochrome c oxidase deficiency
A detailed description of the molecular mechanisms can be found in Segovia-Roldan et al
Zegers-Hochschild, F
