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Under conditions of nutrient deprivation, HCC cells activate ketolysis, leading to the accumulation of ketone bodies such as -hydroxybutyric acid (-HB) and acetoacetic acid in the microenvironment

Frolova O, Frankel A, Cortes J, Kantarjian HM, Andreeff M , Konopleva M

Mitochondrial -oxidation of free fatty acids are related to the conversion of oxidized cofactors (FAD and NAD + ) into reduced cofactors, namely FADH 2 and NADH

V.LesovoyD

L-Carnitine plays a role in managing insulin resistance by boosting insulin sensitivity and aiding in blood sugar regulation

Finally, SOD3 requires copper-zinc as a cofactor and is located in the extracellular space