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Inhibition of the BCL-2 pathway induced apoptosis of some senescent cell types, such as mouse and human fibroblasts, HUVECs, as well as cells of the lung and epidermis, but not primary human preadipocytes (60, 61)

The Open Orthopaedics Journal

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Another school of thought is that not enough fiber in the diet is responsible

Any references to tissue, vascular, or gastrointestinal models are provided only for research context and do not imply therapeutic or clinical use