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In the large intestine, mucus forms two layers: a dense mucous layer in the proximity of epithelial cells, which is normally impenetrable to bacteria, and the loose mucous layer, which is colonized by commensals

But the reality is that for most of my patients, food alone isnt enough anymore

Patients come to the clinician because of back pain, not because they are worried about disc degeneration 9

Schwann cells, which are highly sensitive to metabolic and energy states during myelination, rely on purine metabolism for lipid synthesis, myelin protein expression, and regulation of small GTPasesall crucial for the formation and maintenance of myelin (Montani et al., 2018

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