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Vgontzas AN, Fernandez-Mendoza J, Liao D, Bixler EO (2013) Insomnia with Objective Short Sleep Duration: the Most Biologically Severe Phenotype of the Disorder

Mitochondrial Dysfunction and Oxidative Stress Hepatic mitochondrial dysfunction has a critical role in the development of MASLD by increasing oxidative stress, contributing to inflammation and impaired hepatic insulin resistance (4)

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This led researchers to look at the tumor microenvironment and found significant increases in GSTp [95,96,97]