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These medical disorders are probably caused by the extensive expression of angiotensin-converting enzyme 2 (ACE2) receptor (i.e., facilitator of SARS-CoV-2 entering cells) and many dysfunctional biological processes (such as chronic inflammation, endocrine disorders, immune disorders, tissue damage, tissue hypoxia, dysbacteriosis, coagulation and endothelial abnormalities, and neurological signal dysfunction) (Szabo et al., 2023

Ethics declarations Competing interests J.M.J., J.F.H., I.B., J.M.M., B.H., K.P., J.J.F., S.S., A.S., S.L., K.R

KEYWORDS: Oxidative stress, inflammation, adaptation, ergogenic aid 1

Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia

Cytokines such as IL-1 and TNF-, which are pivotal in inflammation, also serve as sleep-regulating molecules, promoting NREM sleep at physiological levels but contributing to sleep fragmentation when chronically elevated (Zielinski and Gibbons, 2022)

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