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This metabolic imbalance contributes to increased lipid peroxidation, as indicated by high malondialdehyde (MDA) levels ( These mitochondrial impairments not only compromise energy production but also act as pro-inflammatory stimuli, promoting chronic neuroinflammation through dysregulated mitochondrial signaling and innate immune response

Moreover, Cheng and colleagues constructed nickel nanotubes with varying thicknesses of silica nanoshells [68]

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Stadelmann C, Kerschensteiner M, Misgeld T et al (2002) BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells

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Beyond directly controlling metabolic enzymes, AMPK also modulates the cells broader metabolic network through transcription factors [90]