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As part of the office visit, your doctor will take a complete medical history, including asking you about: Your general health Medications you take Your joint pain and other symptoms when they started and whether the symptoms have changed over time Whether you or any family member has a history of arthritis or any autoimmune disorders Physical Examination During the physical examination, your doctor will look for: Signs of RA, including swollen or tender joints, limitation of joint motions, and early deformity

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Medications in this category include: Metformin, H2 blockers and PPI (proton pump inhibitors) used to block acid production in the GI tract

Additionally, these modifications may induce significant toxicity by triggering immune responses 46,47

These analyses were performed by R (version 3.6.3) and R Studio (1.1.442)