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Upon arrival at UTMB, the 18-week-old mice were single-housed and provided ad libitum access to water and a Western diet (WD

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Observational studies A large number of cross-sectional and prospective cohort studies have associated elevated blood homocysteine concentrations with measures of poor cognitive scores and increased risk of dementia, including Alzheimer's disease (reviewed in 67, 69)

Pathways related to immunoglobulin, production, defense responses and B cell activation were among those downregulated, including immunoglobulin production ( IGKV112 , IGKV117 ), adaptive immune response (for example, CX3CR1 , FCGR1BP ) and B cell activation ( HDAC9 , CD180 , MNDA ) (Extended Data Fig