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The substrates and products of the DHODH reaction have opposite effects on ferroptosis, suggesting that the potential role of DHODH in regulating ferroptosis sensitivity is independent of its function of producing pyrimidine nucleotides

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A recent study also suggests that inhibition of pannexins, a family of transmembrane channel forming proteins linking the cytosol to the extracellular environment, alleviates APAP-induced hepatotoxicity [150]

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P., Komninou, D., Leutzinger, Y., Kleinman, W., Orentreich, N., & Frei, B

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