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Mitochondrial dysfunction in chronic obstructive pulmonary disease: unraveling the molecular nexus

Treatment with SOD has experimentally been shown to reduce liver oxidative stress in diabetic animals.[79] SOD mimetic (Mn[II][pyane] Cl2) has successfully been used to treat diabetes in diabetic rats.[80] Chemically modified SOD (carboxymethylcellulose-SOD and poly methyl vinyl ether-co-maleic anhydride-SOD) was effective in treating diabetes and offers a therapeutic advantage in clinical use.[81] It has been demonstrated that extracellular SOD can act as a therapeutic agent to protect the progression of diabetic nephropathy.[82] Current limitations of SODs for therapeutic applications Due to the instability, high immunogenicity, low cellular uptake, and lesser circulation in vivo half-life of SOD, their clinical applications as therapeutic agents are very limited

Oncol Res

While tirzepatide preserves lean mass better than diet alone, some researchers look for ways to further protect muscle during aggressive weight loss

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Schachar JS, Evans RJ, Parks GE, Zambon J, Badlani G, Walker SJ