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High glucose exposure drives intestinal barrier dysfunction by altering its morphological, structural and functional properties

Allegra L, Moavero NE, Rampoldi C

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Using a preclinical model, the authors evidenced that chronically fentanyl-treated animals (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) lost both fat and lean mass during early and late drug administration, as well as during early withdrawal, independently from aging (Mitzelfelt et al., 2011)