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Targeted inhibition of NNMT improves insulin responsiveness and may protect against diet-induced obesity. Hong et al., Nature Medicine Longevity and Anti-Aging Potential Because NAD is vital for DNA repair, circadian rhythm regulation, and mitochondrial health, 5-Amino-1MQ is being explored as a geroprotective agent especially when stacked with NAD boosters or sirtuin activators

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Some substances get punted to February 2027 or later if the committee feels the data are insufficient

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[DOI] [PubMed] [Google Scholar] 65.Roberts C, Robinson SP

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