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Activation of KORs (expressed in the spinal dorsal horn) can block the release of excitatory neurotransmitters, including glutamate and substance P, which in turn attenuates nociceptive signaling [62]

These mutant mice displayed constitutively active NF-B, which led to a prominent increase in macrophages/microglia, T cells, and key proinflammatory mediators (45)

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Moreover, these proinflammatory effects may pose significant risks for patients with underlying inflammatory conditions

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Notably, normal rats exhibited a superior sagittal sinus pressure of 24 to 27 mmHg and superior mesenteric pressure and portal pressure of 35 mmHg similar to that of the inferior vena cava, though with values at least 1 mmHg higher in the portal vein