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The compounds quinolinium scaffold confers membrane permeability that enables intracellular enzyme inhibition, distinguishing it from earlier polar NNMT inhibitor scaffolds that did not effectively enter intact cells

They also benefit those with specific medical conditions, such as chronic fatigue or difficulty losing weight

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These were not anaphylactic reactions

Therefore, in patients with renal or hepatic insufficiency (or both), arginine is generally avoided or only administered with extreme caution under close monitoring