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Encapsulated ferulic acid exhibited antioxidant properties by reducing CCl 4 -induced cytotoxicity in vitro and significantly alleviated hepatotoxicity, ROS production, and tissue damage in rat liver following intravenous administration (139)

The activation of major histocompatibility complex (MHC) Class II-dependent T-cells by citrullinated neoantigens promotes B-cells production of more ACPAs and the activation of inflammatory mediators like TNF-, IL-1, IL-6, and NF-B, leading to pannus formationa thickened synovial layer that invades and destroys cartilage and bone

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