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In another study Vacca et al., did a retrospective study and assessed mouse models using a human proximity score derived from metabolic phenotypes, liver histopathology and transcriptomic similarity to human liver data (302)
doi: 10.1097/CMR.0000000000000489
Cormio L, Zucchi A, Lorusso F, Selvaggio O, Fioretti F, Porena M, et al
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome
A ketogenic diet substantially reshapes the human metabolome
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