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Inhibition of ferroptosis has been found to dampen the ability of M

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In this study, we showed that Tim-AIII suppressed cell proliferation and migration, induced G2/M phase arrest and ultimately triggered cell death of non-small cell lung cancer (NSCLC) cell lines accompanied by the release of reactive oxygen species (ROS) and iron accumulation, malondialdehyde (MDA) production, and glutathione (GSH) depletion

Importantly, unlike disruption of other essential amino acid transporters, genetic ablation of SLC7A11 enhance susceptibility to cell death via ferroptosis (Daher et al., 2019)

In a comparative analysis carried out by Henkenius et al., the metabolic reactions of AML and SCLC cells when exposed to cytarabine or sorafenib were scrutinized