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J Pharmacol Sci (2022) 148(1):7385

doi: 10.1126/science.1115360

Besides intact cell membranes, extracellular vesicles (including exosomes, microvesicles, and apoptotic bodies) and various viral vectors originating from mammalian viruses, bacteriophages, and plant viruses also serve as natural membrane substrates [33, 34]

Looking beyond GLP-1 and insulin as payloads (a molecule that increasingly appears to be a poor commercial candidate), 29 at least ten companies are working on device-based solutions to administer proteins and monoclonal antibodies orally and some technologies including the RaniPill have reached Phase I

Kidney Int 2006;70:16871693

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