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NRF2 is a master regulator of antioxidant response as a transcription factor regulating expression of several enzymes responsible for glutathione synthesis, including glutamate-cysteine ligase modifier subunit (GCLM) and the glutamate-cysteine catalytic subunit (GCLC), as well as enzymes related to GSH utilization, such as glutathione reductase, glutathione peroxidase and glutathione S transferase (GST) [45,46]

Furthermore, another study [124] with 82 cigarette smokers, oral 2-phenethyl isothiocyanate (PEITC), a cruciferous-based compound from watercress, was able to lead to increased detoxification of the volatile carcinogens, benzene and acrolein with an even stronger effect for those with the null genotype of both GSTM1 and GSTT1

Polyphenols, another class of plantderived compounds found in foods such as green tea, berries, and nuts, possess potent antiinflammatory properties

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In addition to the known effects of GLP1R on blood sugar regulation and stimulation of the hypothalamus to regulate appetite, studies have shown that GLP1R agonists have neuroprotective effects in different animal models of PD