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Administered intravenously, LNPs circulate in the bloodstream and can bind to receptors on vascular endothelial cells to achieve targeted delivery [254,255]

GSH is a primary substrate for enzymatic antioxidant functions and is capable of nonenzymatic radical scavenging.33 The reduced GSH and GPX1 can promote the production of reactive oxygen species (ROS), and the over-expression of ROS can promote the stability and expression of HIF-1.34,35 As a highly conserved transcription factor, HIF-1 can promote the over-expression of other hypoxia-related substrates during hypoxia, such as TGF-1, LOX and collagen, eventually aggravated penile fibrosis.36 Besides, HIF-1 can activate target genes and initiate apoptosis, cell death and autophagy.37,38 In this study, HIF-1 increased significantly in the BCNC group, while NAC down-regulated the over-expression

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doi: 10.1038/nbt0694-601

Fu X, Liang Y, Zhao M, et al

Fecal samples were analyzed using 16 S rRNA sequencing technology, followed by comparative analysis of operational taxonomic units (OTUs) between the experimental and control groups