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a statistical approach

Mitochondrial dysfunction and lipid homeostasis

The activation of mTOR leads to phosphorylation and activation of S6 kinases (S6Ks) and hyperphosphorylation of 4E-binding proteins (4E-BPs), resulting in the acceleration of protein synthesis

However, the authors showed that the treatment effect remained in a time-to-event survival analysis performed to account for dropouts

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The study protocol and procedures were in accordance with the ethical standards outlined in the Declaration of Helsinki and its later amendments (21) and approved by the ethical committee of IUMS (ethical code: IR.MUI.REC.1395.3.929)