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Often studied for its ability to mobilise stem cells and reduce fibrosis

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Apaf-1 functions not only in apoptosis but also as an evolutionarily conserved cytosolic DNA sensor

Our data suggest that a moderate dose of ibuprofen treatment for 7 days significantly altered oxylipins related to different metabolic pathways and revealed significant sex specific differences in livers from ibuprofen treated males and females relative to their vehicle controls

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Challenges and limitations in interpreting the results and future research perspectives in this area are discussed