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Methods 416 , 110379 (2025)

They found that genetic knockdown of USP30 increased CNS mitophagy, protected against dopaminergic neuron loss, and reduced -synuclein aggregation

The m/z values are consistent with the expected isotopic mass distribution pattern

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The induction occurred when Nrf1 or Nrf2 was silenced using siRNA but whether CREB binds to the ARE4 alone or requires the participation of other transcription factors is unknown