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4.7 Rheumatoid Arthritis (RA) RA is a highly prevalent disease with a complex, not yet fully understood etiology that is characterized by auto-Abs and excessive production of proinflammatory cytokines (including tumor necrosis factor-alpha, IL-1, IL-2, IL-6, IL-8, IL-17, interferon-gamma, receptor activator of NFB ligand, and granulocyte macrophage-colony stimulating factor)