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While CB-839 inhibited the proliferation of patient-derived glioma cell lines, it did not affect cell viability (103).In NSCLC, KEAP1 mutant NSCLC cell lines exhibit a dependence on Gln, and the GLS inhibitor CB-839 can inhibit Gln metabolism to exert anti-tumor effects (104)

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Immunostaining of pancreas sections and whole islets For pancreas section staining, harvested pancreases were fixed in 4% paraformaldehyde overnight at 4 C, followed by immersion in 30% sucrose solution for 12 h at 4 C before embedding in O.C.T compound

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Macrophage de novo NAD synthesis specifies immune function in aging and inflammation

deAzevedo, L