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Interestingly, autophagy is regulated by mTOR pathway, and mTOR is activated by relative depletion of glutathione

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In renal disorders, excessive mitochondrial ROS together with ROS derived from NOX enzymes intensify mitochondrial injury and dissipate the organelles membrane potential (40, 41)

However, edaravone causes hypersensitivity and allergic reactions in some patients and may be effective in less than 5% of the ALS population [Writing Group

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[DOI] [PubMed] [Google Scholar] Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, et al