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Pair dosing with serial pharmacodynamics (ERR target genes, energetics) and, where feasible, exposure measurements (plasma/tissue)

Gently flick it until all air bubbles collect on top, and then push the plunger a little bit until the bubbles are gone

Confirm profound pulpal and soft-tissue anaesthesia before extraction

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The NLRP3 inflammasome is a complex consists of a sensor (NLRP3 protein), an adaptor (apoptosis-associated speck-like protein, ASC), and an effector (caspase-1)
