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Moreover, the response in the striatum included an increased transcription of nrf2 , gclm , lat1 , eaac1 , and xct , all of which are involved in antioxidant responses, and L-cys/L-cys 2 and glutamate transporters

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In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later

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In the context of children from the Indian subcontinent and various parts of Asia, exclusion of Hepatitis-A viral (HAV) infection is mandatory before confirming the diagnosis of AIH

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