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Small cell dysplasia refers to small discrete aggregates of hepatocytes with relatively little cytoplasm but otherwise normal nuclear and cytoplasmic cytology

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However, more recent data has challenged this hypothesized diffusion mechanism, showing that the transport of T4 and T3 across the cellular membrane into the cell requires active transport rather than passive diffusion

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Tumor necrosis factor-alpha (TNF-) has been shown to reduce both mRNA and protein levels of C/EBP in the hepatocellular carcinoma cell line Hep3B [100]