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Pramlintide (approved 2005): three-amino-acid substitution enabling solubility, 2-3 daily dosing before meals, approximately 23% weight loss in T2D

Congenital methemoglobinemia resulting from a deficiency in cytochrome b5 has been described

doi: 10.1002/(SICI)1097-0126(200004)49:4 3.0.CO;2-W

Obesity alone or with a history of bariatric surgery is a risk factor (9)
