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However, that may also limit patient enrollment in clinical trials

Beyond GPX4s protection against lipid peroxide-mediated death in conditions like lupus nephritis, the transcription factor NRF2 bolsters cellular redox defenses, while in heart failure, renal proximal tubules sustain high ATP demand through a finely-regulated iron cycleinvolving transferrin endocytosis, DMT1 transport, mitochondrial use, ferritin storage, and ferroportin exportto conserve iron and prevent its urinary loss (119)

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Dry, irritated eyes can trigger eyelid spasms

Cell 163 , 643655 (2015)