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Metabolic shifts toward glycolysis or fatty acid oxidation, as well as altered amino acid metabolism, further contribute to drug tolerance

PMID: 34856147

Moreover, ROS are claimed to play a critical role as signaling molecules for anthocyanin production (Hatier and Gould, 2008)
Also, while some color-changing eye drops claim to have effects that last only a few weeks or months, color changes from PGA eye drops are permanent

doi: 10.1007/s00217-010-1246-2 287 FrakolakiGKekesTLympakiFGiannouVTziaC

10.1007/s00401-008-0438-3
