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427 AKI increases renal tubular epithelial cellderived Wnt proteins, which target mesenchymal fibroblasts and activate the Wnt/-catenin signaling pathway

Other studies have revealed compositional and functional changes in gut microbiota (dysbiosis) and subclinical intestinal inflammation as possible drivers of TJ destabilization and leaky gut in animal models of arthritis and humans with RA [2, 3]

The FeS-binding proteins mitoNEET (also known as CISD1) and NAF1 (also known as CISD2), which have been shown to participate in mitochondrial iron transport, inhibit ferroptosis by protecting mitochondria from lipid peroxidation in cancer cells and acute kidney injury [52, 53]

Additionally, early nonmotor symptomssuch as anosmia, REM sleep behavior disorder (RBD), and gastrointestinal dysfunctionare increasingly identified as prodromal indicators

These non-coding RNAs regulate NRF2 expression and activity through different mechanisms, affecting cellular responses to oxidative stress, inflammation, and other physiological processes [164, 165]

The use of diltiazem hydrochloride in cardiovascular disorders