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[169] [170] [171] Consistent with Coleman's and Leibel's hypothesis, several subsequent studies from Leibel's and Friedman's labs and other groups confirmed that the ob gene encoded a novel hormone that circulated in blood and that could suppress food intake and body weight in ob and wild type mice, but not in db mice

The amylin pathway slows gastric emptying through its own mechanism, and when layered on top of GLP-1 mediated gastric slowing, the combined effect on the gut is more pronounced

10.1111/cmi.12312

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Research focus: Cellular senescence, stress-induced aging models, and senescence-associated secretory phenotype (SASP) biology

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