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It is commonly investigated in preclinical research models relating to metabolic signalling pathways, cellular energy regulation, and enzymatic activity associated with nicotinamide N-methyltransferase (NNMT) interaction studies

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Here, in two clinical trials, the authors show that ImmTOR, previously reported to reduce drug immunogenicity in animal studies, helps mitigate ADA induced by pegylated uricase for treating patients with hyperuricemia.

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