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One of those findings is the abnormal activation and processing of cell death signals by the immune system which in turn lead to necrosis of the cells and stimulate the production of antinuclear antibodies in the process

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Additionally, making these probes into nanoparticles increases their accumulation and retention in tumors [90]

Additionally, its abundance is reduced in patients with various diseases, such as IBD 76 , colorectal cancer 77 , and chronic kidney disease 78