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Conformational plasticity of a BiP-GRP94 chaperone complex

Oral aspartame (75mg/kgbody weight/day) consumption causes oxidative stress in brain21 and its (40mg/kgbw/day) consumption caused oxidative stress in brain,22 liver and kidney,23 and also in immune organs.24 This inadequacy, combined with the general limited knowledge about the safety/potential toxigenic effects of substances widely present in the industrialized diet, motivated the design of the current study

PMID: 26220150

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These modifications alter the structure or modification status of DNA and its associated proteins, thereby regulating gene expression levels and functions