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Deficiency is also particularly common in elderly people, as the ability to absorb B12 decreases with age

4cB12 can be calculated: 4cB12=log10[(holoTC.B12)/MMA.Hcy)]-(age factor) The model 4cB12 is currently considered the best biomarker stratification for B12 status and yields one of five diagnoses: elevated B12, adequate B12, decreased B12, possible B12 deficient, and probably B12 deficient

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Early research shows that MOTS-c may improve insulin sensitivity, support fat loss, boost exercise capacity, reduce inflammation, and help slow age-related muscle loss

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