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Mechanistically, HPE enhanced insulin signaling by increasing the phosphorylation levels of insulin receptor substrate 1 (IRS1), phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), and glucose transporter type 4 (GLUT4) in the liver, thereby activating the IRS1PI3KAKTGLUT4 pathway and improving insulin resistance

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An increase in concentration of serum l-carnitine can increment l-carnitine transportation through skeletal muscles and neuromuscular junctions

Sharma et al., 2019)

After 0.5 h, the radio activity initially held by [1- 14 C] palmitate was recovered on labelled short molecules released from the -oxidative cycle and soluble in perchloric acid (acid-soluble products, ASP)

UPR is a highly conserved pathway that monitors endoplasmic reticulum (ER) proteostasis, allowing cells to manage ER stress (Moncan et al., 2021)